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Fissio K-nan
What is Fissio K-nan?
Fissio K-nan is a dog and equine cream formulated with CBD, natural extracts of arnica, hypericum, devil's claw, horse chestnut, eucalyptus and peppermint.
What is it indicated for?
Fissio K-nan is indicated for the care of muscles, joints and ligaments. It combines Cannabidiol (CBD) [1] with natural extracts with anti-inflammatory, analgesic and vasodilator properties such as devil's claw,[2] arnica,[3] hypericum [4] and horse chestnut.[5] The CBD is encapsulated in liposomes to improve the penetration of the active ingredient into the deeper layers of the skin, improving its bioavailability. It also includes a vanillin derivative which, in addition to providing a progressive sensation of warmth on the applied area, favors the activation of blood microcirculation, enhancing the effect of the active ingredients.[1]
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Fissio K-nan is a dog and equine cream formulated with CBD, natural extracts of arnica, hypericum, devil's claw, horse chestnut, eucalyptus and peppermint.
What is it indicated for?
Fissio K-nan is indicated for the care of muscles, joints and ligaments. It combines Cannabidiol (CBD) [1] with natural extracts with anti-inflammatory, analgesic and vasodilator properties such as devil's claw,[2] arnica,[3] hypericum [4] and horse chestnut.[5] The CBD is encapsulated in liposomes to improve the penetration of the active ingredient into the deeper layers of the skin, improving its bioavailability. It also includes a vanillin derivative which, in addition to providing a progressive sensation of warmth on the applied area, favors the activation of blood microcirculation, enhancing the effect of the active ingredients.[1]
What are its active ingredients?
CBD [1] is the main non-psychoactive component extracted from the hemp plant. CBD acts directly on the nervous system through the TRPV1 and PPAR receptors that modulate the response of pro-inflammatory mediators by reducing their expression, as well as producing a notable analgesic effect through its interaction with the receptor belonging to the CB2 cannabinoid system. On the other hand, CBD has been shown to have an antioxidant function, protecting the skin from damage caused by free radicals, which makes its application in the care and maintenance of the most sensitive skins very interesting.Harpagophytum procumbens [2] is famous for its anti-inflammatory and analgesic effect. Harpagophytum extract has been widely used in the treatment of muscle pain and chronic joint pain, making it particularly suitable for the treatment of pathologies resulting from intense sporting activity.
Arnica montana,[3] as well as having good anti-inflammatory and antiseptic properties, helps to activate blood circulation and strengthen the immune system, making it an excellent ally in the treatment of acne, eczema and irritated skin.
Hypericum perforatum [4] is particularly suitable for topical use in the treatment of numerous skin conditions, and its anti-inflammatory and analgesic action makes it an interesting active ingredient for treating bruises and for use in sports medicine.
Aesculus hippocastanum [5] helps to decongest the blood vessels, making it very suitable for treating vascular problems on both the scalp and the skin. It is also said to have anti-inflammatory, antioxidant, homeostatic, healing and anti-oxidant properties.
Vanillyl butyl ether (VBE) [6] induces the so-called "heat effect" through its interaction with the non-selective cation channel "Transient Potential Vanilloid Receptor 1" (TRPV1), which is found in both the "central nervous system" and the "peripheral nervous system". This receptor is responsible for detecting and responding to various stimuli such as high temperatures or irritants. VBE, when interacting with TRPV1, causes TRPV1 to open, allowing ions to pass through the plasma membrane, inducing an action potential in the thermal nociceptors responsible for the sensation of heat.
1] Cital, S. Kramer, K. Hughston, L. Gaynor, J. (2021). Cannabis Therapy in Veterinary Medicine: A Complete Guide. Springer. https://doi.org/10.1007/978-3-030-68317-7
[2] Brendler T. (2021). From Bush Medicine to Modern Phytopharmaceutical: A Bibliographic Review of Devil's Claw (Harpagophytum spp.). Pharmaceuticals (Basel, Switzerland), 14(8), 726. https://doi.org/10.3390/ph14080726
[3] Sherban, A., Wang, J. V., & Geronemus, R. G. (2021). Growing role for arnica in cosmetic dermatology: Lose the bruise. Journal of cosmetic dermatology, 20(7), 2062–2068. https://doi.org/10.1111/jocd.14191
[4] Wölfle, U., Seelinger, G., & Schempp, C. M. (2014). Topical application of St. John's wort (Hypericum perforatum). Planta medica, 80(2-3), 109–120. https://doi.org/10.1055/s-0033-1351019
[5] ittler, M. H., & Ernst, E. (2012). Horse chestnut seed extract for chronic venous insufficiency. The Cochrane database of systematic reviews, 11(11), CD003230. https://doi.org/10.1002/14651858.CD003230.pub4
[6] Oka, Y., Takahashi, K., & Ohta, T. (2022). The effects of vanilloid analogues structurally related to capsaicin on the transient receptor potential vanilloid 1 channel. Biochemistry and biophysics reports, 30, 101243. https://doi.org/10.1016/j.bbrep.2022.101243
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