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Contains hemp seed oil
What are its active ingredients?
Hemp seed oil,[1] as well as containing vitamins A, E and C which protect the skin from environmental oxidative damage, is rich in omega 3 and omega 6 fatty acids, which contribute to strengthening the skin's natural barrier, reducing water loss and therefore improving its hydration and elasticity, leaving it soft, smooth and supple. It has a high content of dihomoganmalinoleic acid, which is a precursor of prostanglandin 1, an important anti-inflammatory mediator.

DHA and EPA [2] are non-essential fatty acids that cannot be synthesised efficiently by the body and must be acquired through the diet. They promote the incorporation of fatty acids into epithelial cells, reducing water loss and improving their protective function. They are precursors of eicosanoids essential for the regulation of the skin's physiological functions. They reduce fibrosis and follicular microinflammation, reducing hair loss and are precursors of anti-inflammatory mediators.[4]

Vitamin A [3] is a precursor of beta-carotene, which is needed to protect the skin from free radical damage and maintain its pigmentation. It stimulates collagen biosynthesis, helping to keep skin hydrated, smooth and supple. Both a lack and an excess of vitamin A is associated with various skin pathologies such as alopecia, seborrhoea and Malassezia dermatitis.

Zinc [3] is essential for the biosynthesis of proteins essential for the proper functioning of skin cells, such as collagen. It protects cells from oxidative damage, stabilises sebum production and also acts as an anti-inflammatory and antiseptic. Zinc deficiency in the body can lead to acrodermatitis enteropathica.

Magnesium [5] incorporates fatty acids into the membranes of epithelial cells, reinforcing the skin's protective barrier and helping to keep it hydrated, firm and elastic. Participia is involved in skin homeostasis and cell regeneration processes, protecting the skin from damage caused by external agents and reducing elastin degradation, helping to keep the skin firmer.

How much does each softgel provide?

[1] Callaway, J., Schwab, U., Harvima, I., Halonen, P., Mykkänen, O., Hyvönen, P., & Järvinen, T. (2005). Efficacy of dietary hempseed oil in patients with atopic dermatitis. The Journal of dermatological treatment, 16(2), 87–94. https://doi.org/10.1080/09546630510035832
[2] David F Horrobin, Essential fatty acid metabolism and its modification in atopic eczema, The American Journal of Clinical Nutrition, Volume 71, Issue 1, January 2000, Pages 367s–372s, https://doi.org/10.1093/ajcn/71.1.367s
[3] Hensel P. (2010). Nutrition and skin diseases in veterinary medicine. Clinics in dermatology, 28(6), 686–693. https://doi.org/10.1016/j.clindermatol.2010.03.031
[4] Witzel-Rollins, A., Murphy, M., Becvarova, I., Werre, S. R., Cadiergues, M. C., & Meyer, H. (2019). Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs. BMC veterinary research, 15(1), 220. https://doi.org/10.1186/s12917-019-1929-2
[5] Coger, V., Million, N., Rehbock, C., Sures, B., Nachev, M., Barcikowski, S., Wistuba, N., Strauß, S., & Vogt, P. M. (2019). Tissue Concentrations of Zinc, Iron, Copper, and Magnesium During the Phases of Full Thickness Wound Healing in a Rodent Model. Biological trace element research, 191(1), 167–176. https://doi.org/10.1007/s12011-018-1600-y
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